Chemokine (C-X-C motif) ligand 12 signaling pathway

Across TCGA patient cohorts, RNA activity of the Chemokine (C-X-C motif) ligand 12 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTK, RPL12P31, and OSBPL6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemokine (C-X-C motif) ligand 12 signaling pathway activity versus TTK in LUAD (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	TTK →	-0.993	-0.175	<.001	.002	3	4
LUAD	RPL12P31 →	-0.430	-0.179	.001	.001	3	4
CCRCC	OSBPL6 →	+0.258	+0.129	.001	.006	3	3
LUAD	TBC1D31 →	-0.468	-0.211	<.001	<.001	3	3
BRCA	PLK1 →	-0.736	-0.387	.003	.001	3	3
LUAD	AQP9 →	-0.876	-0.174	.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038146 vs TTK — LUAD

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