Chemokine (C-X-C motif) ligand 12 signaling pathway

Across TCGA cell cohorts, RNA activity of the Chemokine (C-X-C motif) ligand 12 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AIG1, CDON, and IL11RA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, AIG1 grouped by Chemokine (C-X-C motif) ligand 12 signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	AIG1 →	-0.944	-0.803	.003	.004	3	5
BLOOD_Myeloma	CDON →	+1.961	+1.932	.001	<.001	3	5
SOFT_TISSUE	IL11RA →	+1.888	+1.656	.002	.005	2	5
BONE	KLHL15 →	+0.758	+1.170	.004	.006	3	4
LARGE_INTESTINE	FAM136A →	+0.645	+1.369	<.001	<.001	3	4
LUNG_SCLC	HPS3 →	-0.832	-1.250	.006	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

AIG1 by Chemokine (C-X-C motif) ligand 12 signaling pathway activity — BREAST

Explore this box plot interactively →