Chemokine (C-X-C motif) ligand 12 signaling pathway

Across TCGA cell cohorts, RNA activity of the Chemokine (C-X-C motif) ligand 12 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ETFB, ARL6IP4, and SULT1A3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Chemokine (C-X-C motif) ligand 12 signaling pathway activity versus ETFB in CNS (Pearson r = 0.72).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	ETFB →	+1.231	+1.097	<.001	.003	3	4
BREAST	ARL6IP4 →	+0.627	+1.473	.004	.004	3	3
BREAST	SULT1A3 →	-2.000	-1.377	.007	.005	2	4
PANCREAS	UBP1 →	+0.961	+1.488	.002	.002	3	3
PANCREAS	XYLB →	+0.820	+1.307	.005	.005	3	3
BLOOD_Lymphoma	OSCP1 →	+0.985	+0.191	.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038146 vs ETFB — CNS

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