Macrophage colony-stimulating factor signaling pathway

Across TCGA patient cohorts, RNA activity of the Macrophage colony-stimulating factor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOK1, RGS19_S65, and RTN1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage colony-stimulating factor signaling pathway activity versus DOK1 in BRCA (Pearson r = 0.19).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DOK1 →	+0.397	+0.084	<.001	<.001	3	8
PDAC	RGS19_S65 →	+0.752	+0.043	<.001	.002	3	7
LUAD	RTN1 →	+0.447	+0.089	<.001	<.001	3	7
LSCC	SPN_S368 →	+0.697	+0.084	<.001	<.001	3	7
GBM	TRIM21 →	+0.318	+0.088	.005	<.001	3	7
LSCC	DOCK10 →	+0.440	+0.092	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038145 vs DOK1 — BRCA

Explore this scatter interactively →