Macrophage colony-stimulating factor signaling pathway

Across TCGA patient cohorts, RNA activity of the Macrophage colony-stimulating factor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SAMSN1, FCER1G, and RNASE6, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Macrophage colony-stimulating factor signaling pathway activity versus SAMSN1 in GBM (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SAMSN1 →	+0.773	+0.741	<.001	<.001	3	4
GBM	FCER1G →	+1.135	+0.805	<.001	<.001	3	4
GBM	RNASE6 →	+0.879	+0.823	<.001	<.001	3	4
GBM	CSF2RB →	+0.978	+0.683	<.001	.003	3	4
GBM	PHF24 →	-1.176	-0.636	<.001	.003	3	4
GBM	SRGN →	+1.206	+0.768	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038145 vs SAMSN1 — GBM

Explore this scatter interactively →