ERBB2-ERBB4 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2-ERBB4 signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SIPA1L2_S1652, CES2, and ACACA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2-ERBB4 signaling pathway activity versus SIPA1L2_S1652 in CCRCC (Pearson r = -0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SIPA1L2_S1652 →	-0.627	-0.097	.003	.008	3	5
COAD	CES2 →	+0.613	+0.094	<.001	.007	3	5
HNSC	ACACA →	+0.244	+0.129	.004	<.001	3	5
PDAC	SLMAP_S452 →	+0.481	+0.143	<.001	<.001	3	4
HNSC	BAIAP2 →	+0.449	+0.117	<.001	<.001	3	4
BRCA	WIPF2 →	+0.328	+0.078	.005	.001	2	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038135 vs SIPA1L2_S1652 — CCRCC

Explore this scatter interactively →