ERBB2-ERBB4 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2-ERBB4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LETM2, ARIH2OS, and PLAUR, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LETM2 grouped by ERBB2-ERBB4 signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	LETM2 →	-1.873	-0.899	.009	.002	2	5
CNS	ARIH2OS →	+0.479	+0.895	.006	.002	2	4
PANCREAS	PLAUR →	-1.868	-1.329	<.001	<.001	3	3
BREAST	GNG11 →	-1.837	-0.985	.001	.004	3	3
BREAST	LARGE1 →	+1.270	+0.862	.003	<.001	3	3
BREAST	SLC40A1 →	+1.871	+0.722	.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LETM2 by ERBB2-ERBB4 signaling pathway activity — OVARY

Explore this box plot interactively →