ERBB2-EGFR signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2-EGFR signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, EGFR, and ANXA1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2-EGFR signaling pathway activity versus STRBP in OV (Pearson r = -0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	STRBP →	-0.461	-0.070	.001	<.001	3	6
GBM	EGFR →	+1.782	+0.134	<.001	<.001	3	6
HNSC	ANXA1 →	+0.614	+0.112	.001	<.001	3	6
OV	MET →	+1.008	+0.094	.001	<.001	3	6
HNSC	TNKS1BP1_S920 →	+0.487	+0.107	<.001	<.001	3	6
OV	ANXA2 →	+0.538	+0.076	.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038134 vs STRBP — OV

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