ERBB2-EGFR signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB2-EGFR signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EGFR, EGFR-AS1, and ERBB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2-EGFR signaling pathway activity versus EGFR in GBM (Pearson r = 0.59).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	EGFR →	+2.507	+0.996	<.001	<.001	3	5
GBM	EGFR-AS1 →	+2.344	+0.997	<.001	<.001	3	5
BRCA	ERBB2 →	+1.372	+0.574	.001	.002	3	5
LSCC	S100A16 →	+0.715	+0.609	.002	.007	3	5
GBM	NPY1R →	-0.679	-0.503	.005	.004	3	4
HNSC	MROH8 →	-0.450	-0.698	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038134 vs EGFR — GBM

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