ERBB2-EGFR signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2-EGFR signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRB7, BOD1, and PIP4K2A, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, GRB7 grouped by ERBB2-EGFR signaling pathway-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	GRB7 →	+3.603	+2.260	<.001	<.001	3	6
BREAST	BOD1 →	-0.651	-0.895	<.001	<.001	3	5
BREAST	PIP4K2A →	-0.756	-1.123	.004	<.001	3	5
LUNG_NSCLC_LUAD	CLDN4 →	+2.284	+1.155	.002	<.001	3	5
LIVER	SLC36A1 →	-0.799	-1.812	<.001	<.001	3	5
LUNG_NSCLC_LUAD	MARVELD3 →	+1.627	+1.185	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GRB7 by ERBB2-EGFR signaling pathway activity — LIVER

Explore this box plot interactively →