ERBB2-EGFR signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2-EGFR signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are JPH2, CFLAR, and KIAA0930, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, JPH2 grouped by ERBB2-EGFR signaling pathway-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	JPH2 →	-0.192	-0.182	.002	.001	3	4
LARGE_INTESTINE	CFLAR →	+0.245	+0.172	<.001	.001	3	4
LUNG_SCLC	KIAA0930 →	+0.230	+1.816	<.001	<.001	3	4
LUNG_SCLC	MBD3L1 →	-0.393	-1.621	.002	<.001	3	4
LUNG_SCLC	SOX11 →	-0.136	-1.261	.003	.005	3	4
LUNG_SCLC	ATXN3 →	-0.161	-1.324	.002	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

JPH2 by ERBB2-EGFR signaling pathway activity — OVARY

Explore this box plot interactively →