ERBB2-EGFR signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB2-EGFR signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GARS1, NCEH1, and EGFR, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB2-EGFR signaling pathway activity versus GARS1 in LARGE_INTESTINE (Pearson r = 0.69).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GARS1 →	+1.299	+1.782	.003	<.001	3	2
LARGE_INTESTINE	NCEH1 →	+1.412	+1.485	.007	.009	3	2
LARGE_INTESTINE	EGFR →	+3.009	+1.913	<.001	<.001	3	2
LARGE_INTESTINE	SYT15 →	+0.662	+1.821	<.001	<.001	3	2
PANCREAS	TBC1D24 →	+0.612	+0.396	.005	.005	3	2
LUNG_NSCLC_LUAD	MFNG →	+1.585	+1.688	.007	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038134 vs GARS1 — LARGE_INTESTINE

Explore this scatter interactively →