ERBB4 signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GRB7, ERBB2, and TOX3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB4 signaling pathway activity versus GRB7 in BRCA (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	GRB7 →	+1.811	+0.970	<.001	<.001	3	4
BRCA	ERBB2 →	+1.289	+0.590	<.001	<.001	3	4
BRCA	TOX3 →	+1.431	+0.742	<.001	<.001	3	3
PDAC	BIK →	+0.523	+0.437	.001	.008	3	3
BRCA	MIEN1 →	+1.683	+0.858	<.001	<.001	3	3
PDAC	ADAM3B →	-0.220	-0.343	.002	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038130 vs GRB7 — BRCA

Explore this scatter interactively →