ERBB4 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB4 signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ERBB2, ERBB4, and HBEGF, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ERBB2 grouped by ERBB4 signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	ERBB2 →	-0.460	-0.907	<.001	<.001	3	12
CNS	ERBB4 →	-0.216	-0.961	.006	.006	3	6
SKIN	HBEGF →	-0.385	-1.188	<.001	.002	2	6
BLOOD_Leukemia	SOX21 →	-0.156	-0.620	.004	.006	3	4
BONE	TIE1 →	-0.264	-1.562	.003	.006	3	4
CNS	PLAUR →	-0.250	-0.930	.002	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ERBB2 by ERBB4 signaling pathway activity — BREAST

Explore this box plot interactively →