ERBB4 signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB4 signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WASL, FSCN3, and CLTRN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WASL grouped by ERBB4 signaling pathway-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	WASL →	+0.505	+0.767	.005	.006	3	5
LUNG_SCLC	FSCN3 →	+0.413	+1.259	<.001	.002	3	5
LUNG_NSCLC_LUAD	CLTRN →	+1.230	+1.232	.002	<.001	3	4
OVARY	ETS1 →	-2.518	-1.067	.001	<.001	3	4
OVARY	SLC35G2 →	-1.534	-0.823	.008	.005	3	4
BREAST	CAVIN1 →	-2.689	-0.920	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WASL by ERBB4 signaling pathway activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →