ERBB signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are HPGDS, RFC1_S368, and RPL5, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB signaling pathway activity versus HPGDS in BRCA (Pearson r = 0.32).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HPGDS →	+0.518	+0.029	<.001	<.001	3	7
LUAD	RFC1_S368 →	-0.627	-0.024	<.001	.005	3	6
BRCA	RPL5 →	-0.238	-0.023	<.001	<.001	3	6
CCRCC	NOLC1 →	-0.257	-0.032	.001	<.001	3	6
BRCA	RIF1_S782 →	-0.704	-0.024	<.001	<.001	3	6
BRCA	FGF1 →	+0.439	+0.017	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038127 vs HPGDS — BRCA

Explore this scatter interactively →