ERBB signaling pathway

Across TCGA patient cohorts, RNA activity of the ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are VNN1, IL13RA1, and TC2N, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB signaling pathway activity versus VNN1 in OV (Pearson r = 0.03).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VNN1 →	+1.268	+0.267	.003	.006	3	2
OV	IL13RA1 →	+0.570	+0.170	.003	.002	3	2
OV	TC2N →	+0.655	+0.204	.006	.008	3	2
BRCA	ADRB2 →	+0.819	+0.175	<.001	.002	3	2
OV	LRG1 →	+2.150	+0.292	<.001	.001	3	2
OV	GNG12 →	+0.512	+0.161	.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038127 vs VNN1 — OV

Explore this scatter interactively →