ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNIP1, FNDC3B, and HBEGF, each associated with the pathway in up to 14 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB signaling pathway activity versus TNIP1 in CNS (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	TNIP1 →	+1.237	+0.071	<.001	<.001	3	14
BONE	FNDC3B →	+2.209	+0.110	<.001	<.001	3	13
CNS	HBEGF →	+2.068	+0.052	<.001	<.001	3	13
BONE	GBP3 →	+3.187	+0.105	<.001	<.001	3	13
BONE	LPP →	+1.501	+0.072	<.001	<.001	3	13
BONE	CD82 →	+2.417	+0.067	<.001	.007	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038127 vs TNIP1 — CNS

Explore this scatter interactively →