ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF1C, GFUS, and CCDC86, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB signaling pathway activity versus KIF1C in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	KIF1C →	+0.836	+0.212	<.001	.002	3	4
OESOPHAGUS	GFUS →	+1.168	+0.296	.004	<.001	3	4
PANCREAS	CCDC86 →	+1.254	+0.339	<.001	.007	3	4
CNS	LPXN →	+1.797	+0.204	.007	.008	3	4
SKIN	BRMS1 →	+0.584	+0.171	.002	.001	3	4
CNS	GADD45GIP1 →	+0.535	+0.174	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038127 vs KIF1C — BLOOD_Lymphoma

Explore this scatter interactively →