ERBB signaling pathway

Across TCGA cell cohorts, RNA activity of the ERBB signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the URINARY_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MATR3, CPNE3, and COPB2, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, ERBB signaling pathway activity versus MATR3 in URINARY_TRACT (Pearson r = -0.58).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	MATR3 →	-0.684	-0.338	.001	.001	3	11
OVARY	CPNE3 →	+1.443	+0.823	<.001	.004	3	10
PANCREAS	COPB2 →	+0.902	+0.237	.008	.002	2	11
OVARY	CAPNS1 →	+1.216	+0.512	<.001	.002	3	9
LARGE_INTESTINE	COPA →	+0.747	+0.167	<.001	<.001	3	9
URINARY_TRACT	PSMD5 →	+1.579	+0.350	.006	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038127 vs MATR3 — URINARY_TRACT

Explore this scatter interactively →