Fc-epsilon receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc-epsilon receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RTN1, SASH3_S97, and SEPTIN1_S315, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc-epsilon receptor signaling pathway activity versus RTN1 in OV (Pearson r = 0.41).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RTN1 →	+0.607	+0.055	<.001	<.001	3	10
HNSC	SASH3_S97 →	+0.870	+0.110	<.001	<.001	3	9
GBM	SEPTIN1_S315 →	+1.056	+0.109	<.001	<.001	3	9
LUAD	TBC1D2B_S155 →	+0.407	+0.070	<.001	<.001	3	9
HNSC	ZAP70 →	+0.591	+0.060	<.001	<.001	3	9
GBM	AIF1 →	+0.748	+0.095	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038095 vs RTN1 — OV

Explore this scatter interactively →