Fc-epsilon receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc-epsilon receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CCR5, TRAT1, and GBP5, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc-epsilon receptor signaling pathway activity versus CCR5 in BRCA (Pearson r = 0.36).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CCR5 →	+0.971	+0.690	<.001	<.001	3	7
BRCA	TRAT1 →	+0.725	+0.526	.001	.002	3	7
LSCC	GBP5 →	+0.633	+0.261	.001	.005	2	8
UCEC	PDCD1LG2 →	+0.607	+0.633	.008	.006	3	7
LUAD	NT5C3AP2 →	+0.727	+0.239	<.001	<.001	3	7
LSCC	TNFSF13B →	+0.663	+0.354	<.001	.007	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038095 vs CCR5 — BRCA

Explore this scatter interactively →