Fc-gamma receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc-gamma receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1B, LPXN, and CSF3R, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc-gamma receptor signaling pathway activity versus FCGR1B in GBM (Pearson r = 0.46).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1B →	+0.927	+0.307	<.001	<.001	3	8
HNSC	LPXN →	+0.673	+0.158	<.001	.001	3	7
GBM	CSF3R →	+1.181	+0.297	<.001	<.001	3	7
GBM	FCGR1CP →	+0.856	+0.218	.002	<.001	3	7
GBM	NCF4 →	+0.986	+0.240	<.001	<.001	3	6
HNSC	TLR8 →	+0.895	+0.212	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038094 vs FCGR1B — GBM

Explore this scatter interactively →