Fc-gamma receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc-gamma receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POU1F1, PPP2R2D, and RPS18, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POU1F1 grouped by Fc-gamma receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	POU1F1 →	+0.217	+1.501	.008	<.001	3	4
OESOPHAGUS	PPP2R2D →	+0.204	+1.189	.003	.002	2	5
PANCREAS	RPS18 →	-0.173	-1.362	.008	.002	3	4
URINARY_TRACT	PGM1 →	+0.207	+1.662	<.001	<.001	3	3
LUNG_SCLC	RAB3A →	+0.167	+1.144	<.001	.002	3	3
CNS	NPY5R →	-0.151	-1.266	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POU1F1 by Fc-gamma receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →