Fc receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FCGR1A, FCGR1B, and FCGR1CP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc receptor signaling pathway activity versus FCGR1A in GBM (Pearson r = 0.30).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FCGR1A →	+0.766	+0.137	<.001	<.001	3	7
GBM	FCGR1B →	+0.545	+0.128	<.001	<.001	3	7
GBM	FCGR1CP →	+0.892	+0.137	<.001	.001	3	7
GBM	TRAF3IP3 →	+0.409	+0.120	<.001	<.001	3	7
HNSC	TLR8 →	+0.763	+0.251	.003	.008	3	6
HNSC	TNFSF13B →	+1.193	+0.317	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038093 vs FCGR1A — GBM

Explore this scatter interactively →