Fc receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Fc receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EVL, SKAP2, and ACSL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc receptor signaling pathway activity versus EVL in LSCC (Pearson r = 0.23).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	EVL →	+0.502	+0.329	<.001	<.001	3	5
GBM	SKAP2 →	+0.755	+0.170	<.001	<.001	3	4
HNSC	ACSL5 →	+0.515	+0.326	<.001	<.001	3	4
HNSC	WAS →	+0.444	+0.283	<.001	.003	3	4
LSCC	CCDC88B_S597 →	+0.570	+0.279	<.001	<.001	3	4
GBM	CYRIB →	+0.424	+0.212	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038093 vs EVL — LSCC

Explore this scatter interactively →