Fc receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EPOR, UBE2K, and SYCP2L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EPOR grouped by Fc receptor signaling pathway-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	EPOR →	+0.288	+1.668	<.001	<.001	3	4
BLOOD_Lymphoma	UBE2K →	-0.286	-1.764	.004	<.001	2	4
SKIN	SYCP2L →	-0.246	-0.503	<.001	<.001	3	3
LUNG_NSCLC_LUAD	NUCKS1 →	+0.123	+1.077	.005	.002	3	3
BLOOD_Leukemia	EPHA4 →	-0.242	-1.233	<.001	.009	3	3
BLOOD_Leukemia	MBTPS2 →	+0.200	+1.892	.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EPOR by Fc receptor signaling pathway activity — BLOOD_Leukemia

Explore this box plot interactively →