Fc receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Fc receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are XBP1, SLC27A3, and ZNF513, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Fc receptor signaling pathway activity versus XBP1 in BLOOD_Leukemia (Pearson r = -0.38).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	XBP1 →	-1.214	-1.144	.005	.002	2	6
SOFT_TISSUE	SLC27A3 →	+1.233	+1.542	.003	.003	3	3
SOFT_TISSUE	ZNF513 →	+0.723	+1.030	.007	.004	3	3
BLOOD_Lymphoma	HRNR →	+0.377	+0.637	.001	.009	3	3
BLOOD_Leukemia	DERA →	-0.655	-0.837	.003	.009	3	3
SOFT_TISSUE	PSMB3 →	-0.799	-1.022	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038093 vs XBP1 — BLOOD_Leukemia

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