Nodal signaling pathway

Across TCGA patient cohorts, RNA activity of the Nodal signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1R, C1S, and COL5A2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nodal signaling pathway activity versus C1R in OV (Pearson r = 0.09).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	C1R →	+0.655	+0.060	<.001	<.001	3	5
OV	C1S →	+0.604	+0.059	.001	.003	3	5
LSCC	COL5A2 →	+0.609	+0.074	<.001	<.001	3	5
CCRCC	ANXA2 →	+0.255	+0.059	<.001	<.001	3	5
GBM	P3H4 →	+0.517	+0.080	.003	.001	3	5
BRCA	TLN1_S1641 →	+0.805	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038092 vs C1R — OV

Explore this scatter interactively →