Nodal signaling pathway

Across TCGA patient cohorts, RNA activity of the Nodal signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OMP, ARRDC3, and PLEKHS1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Nodal signaling pathway activity versus OMP in HNSC (Pearson r = -0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	OMP →	-0.332	-0.786	<.001	<.001	3	3
CCRCC	ARRDC3 →	-0.545	-0.648	.002	.003	3	2
BRCA	PLEKHS1 →	-1.099	-0.438	.003	.004	3	2
BRCA	CHML →	-0.715	-0.391	.002	.005	3	2
BRCA	ATP6V1B1-AS1 →	+0.240	+0.431	<.001	<.001	3	2
BRCA	YWHAEP7 →	-0.402	-0.468	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038092 vs OMP — HNSC

Explore this scatter interactively →