Nodal signaling pathway

Across TCGA cell cohorts, RNA activity of the Nodal signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TBX6, ACOT13, and WWP1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TBX6 grouped by Nodal signaling pathway-low versus -high activity in LUNG_NSCLC_LUSC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	TBX6 →	+0.606	+0.789	.002	.003	3	5
PANCREAS	ACOT13 →	-0.871	-1.269	<.001	<.001	3	4
PANCREAS	WWP1 →	+0.626	+1.082	.003	.007	3	4
OESOPHAGUS	IL17RB →	+1.130	+0.763	.008	.007	3	4
SOFT_TISSUE	ARHGAP35 →	-0.602	-1.265	.009	<.001	3	4
STOMACH	DAPK3 →	-0.883	-1.431	.009	.007	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TBX6 by Nodal signaling pathway activity — LUNG_NSCLC_LUSC

Explore this box plot interactively →