Positive regulation of cell migration by vascular endothelial growth factor signaling pathway

pathway activity — cross-omics
GO:0038089Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Positive regulation of cell migration by vascular endothelial growth factor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RSU1, TLN1, and CNN2, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECRSU1 →+0.426+0.069<.001<.00139
UCECTLN1 →+0.383+0.054<.001<.00139
OVCNN2 →+0.644+0.082<.001<.00139
OVFBLN1 →+0.788+0.081<.001<.00139
CCRCCPRKG1 →+0.735+0.082<.001<.00139
CCRCCFMNL3 →+0.410+0.072<.001<.00139
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

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