Peptidyl-tyrosine autophosphorylation

Across TCGA patient cohorts, RNA activity of the Peptidyl-tyrosine autophosphorylation pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHD2, WIPF1, and FLI1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine autophosphorylation activity versus EHD2 in BRCA (Pearson r = 0.43).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EHD2 →	+0.506	+0.036	.003	.001	3	7
LSCC	WIPF1 →	+0.335	+0.087	<.001	<.001	3	6
LSCC	FLI1 →	+0.424	+0.084	<.001	<.001	3	6
LSCC	IL16 →	+0.514	+0.087	<.001	<.001	3	6
LSCC	PRKCB →	+0.454	+0.069	<.001	<.001	3	6
UCEC	RASSF5 →	+0.566	+0.066	<.001	.009	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038083 vs EHD2 — BRCA

Explore this scatter interactively →