Peptidyl-tyrosine autophosphorylation

Across TCGA cell cohorts, RNA activity of the Peptidyl-tyrosine autophosphorylation pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BNIPL, INAFM2, and SRPX2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Peptidyl-tyrosine autophosphorylation activity versus BNIPL in BREAST (Pearson r = 0.48).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	BNIPL →	+1.932	+1.063	<.001	.005	3	4
UPPER_AERODIGESTIVE_TRACT	INAFM2 →	+1.445	+1.313	<.001	.005	3	4
LUNG_NSCLC_LUSC	SRPX2 →	-3.526	-1.707	.001	.003	3	4
LUNG_NSCLC_LUSC	FLII →	+1.279	+1.660	.002	.004	2	5
OVARY	COG5 →	+1.186	+0.338	.001	.006	3	3
LARGE_INTESTINE	ZGPAT →	+0.746	+0.596	<.001	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038083 vs BNIPL — BREAST

Explore this scatter interactively →