Collagen-activated signaling pathway

Across TCGA patient cohorts, RNA activity of the Collagen-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC2B, UBASH3B, and KCNMB1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen-activated signaling pathway activity versus CLEC2B in GBM (Pearson r = 0.08).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CLEC2B →	+0.928	+0.198	<.001	<.001	3	5
GBM	UBASH3B →	+0.553	+0.211	<.001	<.001	3	5
BRCA	KCNMB1 →	+0.600	+0.532	<.001	.004	3	4
GBM	CTSB →	+0.883	+0.215	<.001	<.001	3	4
GBM	AIF1 →	+0.648	+0.135	.004	.002	2	5
BRCA	SLC39A14 →	+0.415	+0.434	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038065 vs CLEC2B — GBM

Explore this scatter interactively →