Collagen-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Collagen-activated signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBASH3B, DDR2, and COL1A1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, UBASH3B grouped by Collagen-activated signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	UBASH3B →	-0.157	-0.823	.006	.001	3	7
OVARY	DDR2 →	-0.169	-0.879	.002	.004	3	5
CNS	COL1A1 →	-0.196	-0.942	.002	.001	3	5
BLOOD_Myeloma	CYP46A1 →	-0.284	-1.315	.002	.003	3	4
LUNG_NSCLC_LUAD	PAX1 →	-0.171	-0.686	.008	.002	3	4
SKIN	COL4A1 →	-0.278	-1.180	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

UBASH3B by Collagen-activated signaling pathway activity — CNS

Explore this box plot interactively →