Collagen-activated signaling pathway

Across TCGA cell cohorts, RNA activity of the Collagen-activated signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DDR1, ITGA2, and LAMC2, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen-activated signaling pathway activity versus DDR1 in KIDNEY (Pearson r = 0.56).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DDR1 →	+2.259	+0.307	<.001	<.001	3	12
LUNG_NSCLC_LUSC	ITGA2 →	+4.279	+0.405	<.001	<.001	3	9
LUNG_NSCLC_LUAD	LAMC2 →	+2.685	+0.259	<.001	<.001	3	9
SOFT_TISSUE	COL4A1 →	+3.620	+0.179	<.001	.003	3	9
BLOOD_Leukemia	JUP →	+1.547	+0.509	<.001	<.001	3	8
LUNG_NSCLC_LUAD	LAMB3 →	+1.413	+0.213	.001	.005	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038065 vs DDR1 — KIDNEY

Explore this scatter interactively →