Collagen-activated tyrosine kinase receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Collagen-activated tyrosine kinase receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ACTN1, MRC2, and MYH10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen-activated tyrosine kinase receptor signaling pathway activity versus ACTN1 in CCRCC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	ACTN1 →	+0.433	+0.072	<.001	<.001	3	9
COAD	MRC2 →	+0.576	+0.120	<.001	<.001	3	9
CCRCC	MYH10 →	+0.554	+0.067	<.001	<.001	3	9
UCEC	ARHGEF17 →	+0.326	+0.087	.001	<.001	3	9
COAD	RAI14 →	+0.357	+0.107	<.001	<.001	3	9
GBM	COL6A2 →	+0.634	+0.076	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038063 vs ACTN1 — CCRCC

Explore this scatter interactively →