Collagen-activated tyrosine kinase receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Collagen-activated tyrosine kinase receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEACAM4, FAS, and MAP3K8, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Collagen-activated tyrosine kinase receptor signaling pathway activity versus CEACAM4 in GBM (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	CEACAM4 →	+0.619	+0.159	.006	.006	3	4
GBM	FAS →	+0.731	+0.194	.003	<.001	3	4
GBM	MAP3K8 →	+0.585	+0.160	.005	<.001	3	4
GBM	CTSC →	+0.962	+0.187	<.001	.001	3	4
GBM	KCNMB1 →	+0.389	+0.127	.005	.001	3	4
CCRCC	GPR160 →	-0.327	-0.140	.005	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038063 vs CEACAM4 — GBM

Explore this scatter interactively →