Collagen-activated tyrosine kinase receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Collagen-activated tyrosine kinase receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZFP14, ATP7B, and FCRL1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZFP14 grouped by Collagen-activated tyrosine kinase receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	ZFP14 →	-0.187	-0.163	.001	.002	3	5
LUNG_SCLC	ATP7B →	+0.282	+0.281	.002	<.001	3	4
BONE	FCRL1 →	+0.289	+0.254	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	CHMP4A →	-0.244	-0.256	.005	.004	3	4
LARGE_INTESTINE	COBL →	+0.206	+0.278	.005	.002	3	3
LARGE_INTESTINE	CCAR2 →	-0.180	-0.178	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZFP14 by Collagen-activated tyrosine kinase receptor signaling pathway activity — SKIN

Explore this box plot interactively →