Non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Non-canonical NF-kappaB signal transduction pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are RCSD1, WAS, and WIPF1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical NF-kappaB signal transduction activity versus RCSD1 in LSCC (Pearson r = 0.62).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	RCSD1 →	+0.626	+0.071	<.001	<.001	3	10
GBM	WAS →	+0.693	+0.076	<.001	<.001	3	10
LSCC	WIPF1 →	+0.422	+0.071	<.001	<.001	3	10
LSCC	DOCK8 →	+0.602	+0.084	<.001	<.001	3	10
GBM	CORO1A →	+0.671	+0.074	<.001	<.001	3	10
OV	DOCK11 →	+0.501	+0.039	.003	.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038061 vs RCSD1 — LSCC

Explore this scatter interactively →