Non-canonical NF-kappaB signal transduction

Across TCGA patient cohorts, RNA activity of the Non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP85L, DPYSL3, and DCN, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical NF-kappaB signal transduction activity versus CEP85L in COAD (Pearson r = -0.12).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CEP85L →	+0.372	+0.101	<.001	.009	3	5
BRCA	DPYSL3 →	+0.605	+0.125	.003	.007	3	4
BRCA	DCN →	+0.807	+0.132	<.001	.004	3	4
BRCA	PRRX1 →	+0.750	+0.130	<.001	.005	3	4
LUAD	SSPN →	+0.595	+0.136	<.001	.001	3	4
BRCA	BMP2K →	+0.331	+0.185	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038061 vs CEP85L — COAD

Explore this scatter interactively →