Non-canonical NF-kappaB signal transduction

Across TCGA cell cohorts, RNA activity of the Non-canonical NF-kappaB signal transduction pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SLC27A2, ABLIM3, and DRAM1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Non-canonical NF-kappaB signal transduction activity versus SLC27A2 in BONE (Pearson r = -0.33).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	SLC27A2 →	-1.022	-0.243	.002	.009	2	6
STOMACH	ABLIM3 →	-1.922	-0.401	.007	.001	3	5
OVARY	DRAM1 →	-2.151	-0.452	<.001	<.001	3	4
LUNG_SCLC	HADH →	+1.219	+0.568	<.001	.006	3	4
OVARY	BRSK1 →	+1.515	+0.549	<.001	<.001	3	4
PANCREAS	IFIT3 →	-1.730	-0.285	.007	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038061 vs SLC27A2 — BONE

Explore this scatter interactively →