Signal transduction in absence of ligand

Across TCGA patient cohorts, RNA activity of the Signal transduction in absence of ligand pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C4A, NRP2, and APBB2, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction in absence of ligand activity versus C4A in BRCA (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	C4A →	+0.607	+0.027	<.001	<.001	3	7
OV	NRP2 →	+0.595	+0.044	<.001	<.001	3	7
OV	APBB2 →	+0.345	+0.050	<.001	<.001	3	7
OV	RCN3 →	+0.838	+0.063	<.001	<.001	3	6
GBM	SNX6 →	+0.244	+0.043	.001	.001	3	6
GBM	SON →	-0.190	-0.032	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038034 vs C4A — BRCA

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