Signal transduction in absence of ligand

Across TCGA patient cohorts, RNA activity of the Signal transduction in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HSPB8, IL17F, and MAL, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Signal transduction in absence of ligand activity versus HSPB8 in BRCA (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	HSPB8 →	+1.153	+0.170	.004	<.001	3	4
PDAC	IL17F →	-0.037	-0.153	.006	.001	3	4
CCRCC	MAL →	-1.344	-0.162	.001	.002	3	4
UCEC	ZNF516 →	+1.062	+0.216	<.001	<.001	3	3
UCEC	LRRC46 →	+0.954	+0.157	.001	.003	3	3
PDAC	ADGRF1 →	-1.010	-0.166	.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0038034 vs HSPB8 — BRCA

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