Signal transduction in absence of ligand

Across TCGA cell cohorts, RNA activity of the Signal transduction in absence of ligand pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SYT8, EPS8L2, and TMEM131L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SYT8 grouped by Signal transduction in absence of ligand-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	SYT8 →	+1.208	+1.711	.001	.002	3	4
LIVER	EPS8L2 →	+1.603	+1.548	.003	.003	2	5
OVARY	TMEM131L →	-0.751	-1.051	<.001	<.001	3	4
BLOOD_Lymphoma	TRAPPC3 →	-0.597	-2.284	.002	<.001	3	4
LARGE_INTESTINE	UNC5CL →	+1.389	+1.106	<.001	.007	3	4
BLOOD_Leukemia	ZNF391 →	+1.139	+1.102	<.001	.005	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SYT8 by Signal transduction in absence of ligand activity — LIVER

Explore this box plot interactively →