Obsolete non-canonical Wnt signaling pathway via JNK cascade

pathway activity — cross-omics
GO:0038031Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Obsolete non-canonical Wnt signaling pathway via JNK cascade pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CD34, EVL, and FKBP9, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCCD34 →-0.657-0.105<.001<.00137
BRCAEVL →-0.510-0.062<.001<.00136
BRCAFKBP9 →+0.498+0.080<.001<.00136
LSCCGIMAP7 →-0.605-0.179<.001<.00136
BRCAMBP →-0.448-0.077<.001.00336
BRCAPRKCH →-0.310-0.063<.001<.00136
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration