G protein-coupled opioid receptor signaling pathway

pathway activity — cross-omics
GO:0038003Cross-omicsPROTEIN-MS → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the G protein-coupled opioid receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are PPP1R9B_T207, CLIP1_S312, and TNS2_S975, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
CCRCCPPP1R9B_T207 →+1.309+0.368<.001<.00133
GBMCLIP1_S312 →-0.615-0.295<.001<.00133
LUADTNS2_S975 →-0.676-1.312<.001<.00133
LUADTASOR_S633 →+0.669+1.673.001<.00132
CCRCCFARP1_S514 →+0.658+0.229<.001.00414
GBMFMR1_S500 →-0.725-0.334<.001.00132
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration