G protein-coupled opioid receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the G protein-coupled opioid receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are OR52I2, NUP85, and PJA2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, OR52I2 grouped by G protein-coupled opioid receptor signaling pathway-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OR52I2 →	-0.146	-0.276	.002	.001	3	5
BONE	NUP85 →	+0.303	+0.330	.002	.003	3	4
BONE	PJA2 →	-0.467	-0.499	.006	.002	3	4
SKIN	BTRC →	-0.202	-0.277	.001	<.001	3	4
BLOOD_Lymphoma	COL11A2 →	-0.398	-0.451	<.001	.002	3	4
LUNG_NSCLC_LUSC	ERGIC2 →	-0.150	-0.259	.007	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

OR52I2 by G protein-coupled opioid receptor signaling pathway activity — SKIN

Explore this box plot interactively →