Paracrine signaling

Across TCGA cell cohorts, RNA activity of the Paracrine signaling pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are FRAT2, UTP11, and IGSF6, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, FRAT2 grouped by Paracrine signaling-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	FRAT2 →	-0.677	-0.906	.005	.005	3	5
BLOOD_Lymphoma	UTP11 →	-1.082	-1.551	<.001	.002	3	5
OESOPHAGUS	IGSF6 →	+0.268	+1.355	.002	<.001	3	4
LUNG_SCLC	CDC42EP2 →	+1.324	+1.018	<.001	.001	3	4
LUNG_SCLC	SEMA3A →	+2.711	+1.413	.001	<.001	3	4
LARGE_INTESTINE	CENPP →	-0.823	-0.678	.003	.006	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

FRAT2 by Paracrine signaling activity — CNS

Explore this box plot interactively →